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Retatrutide adds a third target: the glucagon receptor
The ultimate cost to the federal government of the Medicare GLP-1 Bridge will depend on actual participation numbers and adherence during the 18-month program, as well as potential cost offsets from savings that might accrue over time due to beneficiary health improvements from GLP-1 use for weight reduction and weight management
A prescription is required for medical and therapeutic peptides
Patients should be aware of important safety considerations, including rare but serious risks such as pancreatitis (seek medical help for severe, persistent abdominal pain), gallbladder problems, and potential effects on diabetic retinopathy, particularly with rapid improvement in blood glucose control
Those familiar with other injectable medications like Victoza often find the transition easier
