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For most patients, reaching goal weight does not signal the end of treatment but rather a transition from the weight loss phase to the weight maintenance phase, which typically requires continued pharmacological support for optimal outcomes as long as benefits outweigh risks

[9] Medical use [edit] Exenatide is used to treat type 2 diabetes as an add-on to metformin, a biguanide, or a combination of metformin and a sulfonylurea, or thiazolidinediones such as pioglitazone

Long-term Use and Weight Maintenance Treat semaglutide as a chronic treatment that changes your physiological baseline while you use it, not a one-time cure

It Improves Insulin Sensitivity Insulin resistance makes weight loss extremely difficult

I think that jury is still out. Its possible that GLP-1s are affecting the brain and body in ways that researchers dont yet fully understand