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The evidence for cardiovascular benefits of GLP-1 RA and SGLT2i in those with only risk factors for CVD, based on MACE (myocardial infarction, stroke or cardiovascular death), is less robust, as fewer people with lower event rates are included in studies [313,314,315]
Because they work by making existing insulin more effective rather than increasing insulin levels directly, hypoglycemia is less of a concern than with sulfonylureas
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It can be a good fit for adults with obesity (BMI 30 and over) overweight adults (BMI over 27) with a weight-related issue like high blood pressure or cholesterol those with type 2 diabetes Its probably not a good fit for women who are pregnant, trying to get pregnant, or breastfeeding, since theres not enough safety data people with type 1 diabetes people with pancreatitis or a history of medullary thyroid cancer True Stories Of Transformation What Is Retatrutide
