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Coffee consumption had a protective effect on gallstone disease, but only after adjusting for BMI and smoking in a multivariable MR (MVMR) model, or in another study looking at only cases of symptomatic gallstone disease (Reference Yuan, Gill and Giovannucci73,Reference Nordestgaard, Stender and Nordestgaard74)

all data are still investigational

Reconstitution technique may have compromised potency

Fourth, predictive biomarkers capable of reliably stratifying patients for immunotherapy and targeted treatments remain suboptimal, contributing to treatment variability and overtreatment in many cases (329)

Results for the Extension Phases of Studies 1 and 2 are presented in Tables 5 and 6