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A 2025 mini-review on older adults warns that starting and stopping GLP-1s repeatedly can change body composition, sometimes leading to sarcopenic obesity having too much fat and too little muscle
However, the range can vary widely
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GLP-1s support weight loss by: Delaying gastric emptying, which helps you feel fuller for longer after meals Regulating blood sugar, which can support steady energy and fewer cravings Reducing appetite and food noise by acting on hunger-regulating areas of the brain While Ozempic, Wegovy, Foundayo, and Zepbound all fall under the GLP-1 umbrella, Zepbound is unique in that it also targets another hormone called GIP (glucose-dependent insulinotropic polypeptide)
The benefits depend on which peptide you're using and your individual response
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