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Consistent drug levels mean consistent receptor activation

The SURPASS-CVOT trial, which directly compared these two medications in over 13,000 people with type 2 diabetes, found that tirzepatide produced approximately 12% weight loss compared with 5% for dulaglutide over 4 years

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Results Between October 2019 and October 2021, a total of 774 participants were screened and 521 participants were randomised to oral semaglutide 3 mg ( n =130), 7 mg ( n =130), 14 mg ( n =130) or placebo ( n =131)