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At equimolar doses, this novel compound, GIC-1001 (trimebutine 3-thiocarbamoylbenzene-sulphonate), shows rapid onset of action (2 h) and more effectively mitigates nociceptive responses to colorectal distension, providing pain relief during colonoscopy (Table 4)
Melatonin: Clinical Perspectives in Neurodegeneration
This rebound effect occurs because the amylin receptor system, having adapted to sustained agonism, temporarily overcompensates when that stimulation is removed
The complex samples were flash frozen in liquid nitrogen and stored at 80C
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