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This is because the coordination state of the copper ions in the GHK-Cu and the tripeptide is crucial to its efficacy, and acidic substances can easily dissociate the copper ions in the complex, which will reduce the activity of superoxide dismutase
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TMAO also upregulated the expression of scavenger receptor cluster of differentiation 36 (CD36) and scavenger receptor-A1 (SR-A1) in macrophages, and induced cholesterol flow to macrophages
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