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On the other hand, the emerging proteolysis targeting chimera (PROTAC) technology, which was introduced by Crews and Deshaies in 2001 via disrupting the endogenous ubiquitin (Ub)-E2 ligase-E3 ligase complex [174], which is widely applicable for degrading abnormal protein targets including epigenetic proteins, may show promise in the treatment of epilepsy

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10.1021/ja504810z J

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Pulmonary fibrosis: pathogenesis, etiology and regulation

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