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The tardive dyskinesia risk is real and must be communicated
Tirzepatide becomes the preferred choice when patients experience plateaus on semaglutide, seek maximum weight reduction potential, or carry genetic markers favoring dual-pathway activation (particularly elevated GIPR or FTO variants)
Shoemaker's research demonstrated that patients with CIRS consistently show severe abnormalities in inflammatory blood markers, including highly elevated TGF-beta1, C4a, and MMP-9, alongside drastically depleted levels of Melanocyte Stimulating Hormone (MSH) and Vasoactive Intestinal Polypeptide (VIP)
However, its possible to manage this side effect with diet and lifestyle changes, as well as over-the-counter (OTC) medicines
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