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While caloric restriction alone often results in loss of both fat and muscle, AOD-9604 preferentially targets adipose tissue

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4.5 Safety profile The safety assessment of GLP-1 receptor agonists indicates a mostly gastrointestinal side effect profile, characterised by dose-dependent symptoms that are often treatable by meticulous titration (Madsbad 2016)

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These changes create NDP--MSH (Nle4, D-Phe7--MSH), which is approximately 100-1000 times more potent than native -MSH at the MC1R receptor and is resistant to enzymatic degradation