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A huge amount of work has been performed to understand the cellular and molecular mechanisms controlling adult neurogenesis particularly in the rodent brain (for reviews see refs
Targeting microglia in Alzheimers disease: pathogenesis and potential therapeutic strategies
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Thus, data in support of each hypothesis was derived from different animal models, with mitochondrial oxidative stress being critical for APAP hepatotoxicity in mice on a normal diet, without appreciable LPO generation
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