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Most Frequent Adverse Events In the key adult ADHD trial (SPD489-305), the following adverse events occurred at rates significantly above placebo, as reported in the FDA label: | Adverse Event | Vyvanse 30-70 mg (%) | Placebo (%) | |---|---|---| | Decreased appetite | 27 | 2 | | Insomnia | 27 | 8 | | Dry mouth | 26 | 3 | | Headache | 20 | 17 | | Nausea | 7 | 3 | | Anxiety | 6 | 3 | Weight Loss and Nutritional Risk Decreased appetite is the most clinically significant side effect for young adults, particularly those with a history of disordered eating

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Severe or frequent hypoglycemia is an indication for the modification of treatment regimens, including setting higher glycemic goals

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