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Every person's weight loss journey is unique, and what works best for you might be different from someone else
Although the exact mechanism of action is not fully understood, it is hypothesised that bupropion stimulates hypothalamic pro-opiomelanocortin (POMC) cell, with downstream effects to reduce food intake and increase energy expenditure
If you stay on the starting dose for too long, your doctor might need to raise it
That does not mean the plan is not working
At least for sitagliptin, it is also known that it lowers the level of free fatty acids (FFA) and thereby also comprises insulin-sensitizing properties (98)
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