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Cell 170, 1733
10.1161/STROKEAHA.115.011956 27 GrosseS
This paradox occurs because the peptide triggers lasting changes in gene expression that continue independently after the peptide clears the system
Interestingly, His1-Gly2 of exendin-4 exhibited weaker density relative to the rest of the peptide in the cryo-EM map, and this is consistent with the enhanced flexibility observed for this region of the bound peptide in the simulations, likely due to Gly2, as glycine can destabilise -helical conformations
Its main goal is to influence important cellular processes related to aging, cellular senescence, and programmed cell death, also known as apoptosis
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