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Importantly, irrespective of endothelial activation, CAMs respond to severely reduced blood flow, shifting to an activated state with morphological changes that support their migration (Masuda et al., 2011)
A net influx of molecules into the CNS would increase osmolarity and allow water from the vasculature to enter the brain, thereby leading to an increase in intracranial pressure
That activation can influence brain circuits tied to sexual motivation and genital arousal, rather than acting purely on blood flow or peripheral tissues like many sexualperformance drugs
Additionally, researchers are looking into the development of oral GLP-1 medications, which could further expand access to this treatment and make it even more convenient for patients to manage their health
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