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Beyond these canonical targets, v3 integrin overexpression on tumor neo-vasculature and invasive cancer cells enables cRGD peptide-mediated dual targeting of angiogenesis and tumor survival, while nucleolin, aberrantly surface-displayed in proliferating breast cancer cells, offers aptamer-based (AS1411) recognition independent of traditional receptor-ligand paradigms [127]
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doi: 10.1146/annurev.phyto.40.021102.150133 63 Ramirez-PradoJ
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