RDN restores diuretic and natriuretic effects of GLP-1 and thus has potential beneficial therapeutic implication for diabetic HF patients
Because the majority of the -cells do not express GLP-1R, and also because GLP-1 inhibits glucagon secretion even in T1D patients with low insulin pancreatic reserve, the mechanism by which GLP-1 decreases glucagon secretion is still a matter of debate [15]
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Arenas J, Ricoy JR, Encinas AR, Pola P, D'Iddio S, Zeviani M, Didonato S, Corsi M
The more cautious interpretation is that patients who receive GLP-1 receptor agonists may differ in important but incompletely measured ways from those treated with insulin or metformin, including overall health, treatment access, healthcare follow-up, or cardiometabolic care intensity