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Nests of melanocytes are found at the dermoepidermal junction and within the dermis

They complement each other: hydroquinone reduces melanin production while tretinoin promotes cell turnover and enhances the penetration of hydroquinone

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Researchers note that this decline coincides with the noticeable decrease in regenerative capacity of an organism. This correlation suggests that decreased natural GHK levels may play a role in slower wound healing observed in older adults