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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)
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Patients were allowed to increase the insulin dose only up to the starting insulin dose prior to randomization
It works by slowing tyrosinase, the enzyme that triggers melanin production
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