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Participants were randomized 1:1 to 100 mg daily aspirin or a placebo

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Zinc Depletion Over Time Long-term use of high-dose glutathione has been linked to lower zinc levels

In February 2026, full results from the REDEFINE 2 study showed CagriSema achieving 23% weight loss at 84 weeks but falling short of its primary endpoint under the treatment policy estimand (which measures efficacy across all patients regardless of whether they completed treatment, rather than only those who remained on it)