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When oxygen and transporter capacity are sufficient, it serves as an oxidative fuel and signaling molecule for neurons, through astrocyte-neuron lactate shuttling [11, 12]
However, because some MDHA will inevitably escape reduction and undergo dismutation, a backup system to deal with DHA is necessary (Fig
"Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis"
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