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Figures 2, 4) availability is maintained by de novo synthesis from precursor amino acids, (glutamate, cysteine, and glycine), reduction of GSSG by glutathione reductase (GR), and uptake from exogenous GSH sources across plasma membranes (Figure 4) ( via specific plasma membrane transporters ( FIGURE 3 FIGURE 4 Glutathione cellular distribution Glutathione is found in almost all cellular compartments, including the nucleus (Figures 2, 4)
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Rubenstein & Merzenich, 2003) involving either or both upregulated glutamatergic excitatory and down-regulated GABAergic inhibitory systems(Sohal & Rubenstein, 2019)
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