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Toxicity appears low, but long-term human safety is unknown
In the STEP and SURMOUNT trials for semaglutide and tirzepatide respectively, weight loss curves generally began to flatten between weeks 36 and 60, reflecting the physiological set point adaptation that occurs as appetite suppression becomes partially offset by metabolic adaptation
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Because long-term studies are limited, the full side-effect profile for most peptides is not yet well understood
It's very clear that a lot of them are contaminated with things that both in the short term, but especially in the long term can be problematic
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