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If pancreatitis is suspected (severe, persistent abdominal pain, particularly if radiating to the back, accompanied by nausea and vomiting), the GLP-1 medication should be discontinued immediately and urgent medical assessment sought
Pharmacotherapy for gestational diabetes
Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration
It is a central one
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