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In October 2024, a multi-society clinical practice guidance document involving anesthesiology, gastroenterology, bariatric, and surgical stakeholders recommended that most patients continue GLP-1 receptor agonists before elective surgery
The main differences are related to the drug delivery process
While some people respond to taking a very small dose called super responders others cannot tolerate moving up to the next higher standard dose and need something in between. This helps explain why one recent study among patients with diabetes found that microdosing helped them stick with their GLP-1s, reducing side effects without compromising efficacy
Whereas the riboflavin biosynthesis pathway is most extensively studied in Bacillus subtilis 32 and Escherichia coli 33 , which can reside in the gut at different levels, one systematic genome assessment has found that each of the eight B vitamins (B1, B2, B3, B5, B6, B7, B9, and B12) can theoretically be produced by 4065% of the 256 studied human gut strains 34
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
