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The STEP trials for semaglutide 2.4 mg (Wegovy) showed: Average weight loss of approximately 15% of body weight over 68 weeks One-third of participants lost 20% or more of body weight Significant reductions in waist circumference, blood pressure, and cardiovascular risk markers The SURMOUNT trials for tirzepatide (Zepbound) showed even more impressive results: Average weight loss of 20-25% at the highest dose (15 mg) over 72 weeks More than half of participants lost 20% or more of body weight Significant improvements in type 2 diabetes markers, blood pressure, and lipid profiles The head-to-head comparison is clear

2010 Mar;16(3):BR81-88

The N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models

Structure Sequence: Glycyl-L-Histidyl-L-Lysine Copper (GHK-Cu) Molecular Formula: C14H24N6O4Cu Molecular Weight: 403.92 g/mol PubChem CID: 3081431 Citations for GHK-Cu Collagen Synthesis & Skin Rejuvenation Pickart, L., et al

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