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These events were dose-dependent, primarily of mild to moderate severity, and were partially alleviated by lower initial doses (2 mg vs
To demonstrate the superior efficacy of the MNs/GLP-1RAs@NPs-WYRGRL in the treatment of RA, rats were divided into NC group, RA group, RA + NPs group, RA + GLP-1RAs@NPs group, RA + GLP-1RAs@NPs-WYRGRL group, RA + MNs group and RA + MNs/GLP-1RAs@NPs-WYRGRL group, with 46 rats in each group
Metformin treatment preserved proteoglycans, reduced cartilage fibrillation and erosion, and attenuated cartilage damage compared with those in OA group (Fig
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