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Research suggests several beneficial mechanisms: Improved insulin sensitivity : Insulin resistance is a key driver of PCOS symptoms, and GLP-1 medications can enhance insulin action Weight loss effects : Even modest weight reduction (510% of body weight) can restore ovulation and regular cycles in women with PCOS [17] [18] Reduced androgen levels : Weight loss and improved insulin sensitivity often lead to decreased testosterone and other androgens Restoration of ovulation : Some women with PCOS who previously had absent periods may begin ovulating regularly NICE Clinical Knowledge Summary on PCOS recommends lifestyle modification and weight loss as first-line interventions for overweight women with the condition
Bridging therapies may be considered but can be costly and risky
DPP-4 inhibitors for type 2 diabetes: Is one approach more successful or preferable than the other
10.3389/fnana.2025.1504065 498 YiY.LuW.ShenL.WuY.ZhangZ
Individual sensitivity varies, but the overwhelming consensus is that its much less unpleasant than expected
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