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These medications target separate endocrine systemsgrowth hormone pathways versus incretin-based glucose metabolismmeaning they do not directly compete for the same receptors

Common reasons include previous intolerance to GLP-1 medications, GI sensitivity concerns , desire for gradual weight loss to minimize loose skin, or interest in metabolic benefits before significant appetite suppression

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19 The dextran-aspirin nanomedicine (P3C-Asp) demonstrated its potential in colorectal cancer (CRC) therapy by releasing salicylic acid, scavenging reactive oxygen species (ROS), and restoring gut microbiota balance

p = 0.55, Supplementary Fig