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These specific estrogen metabolites increase the risk of breast cancer.[ref] Thus, you dont want certain Phase I metabolites hanging around in the body

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According to reports, serum estrogen and tamoxifen levels were positively correlated [35]

Nursing mothers should also consult their gynaecologist before administering these capsules

Dihexa is orally bioavailable in animal models, with cognitive effects comparable to subcutaneous injection a property virtually absent among conventional neuropeptides that require intranasal or injectable delivery (PMID: 23055539)