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The 2018 AHA/ACC cholesterol guideline recommends reassessing PCSK9 inhibitor therapy if patients report new symptoms, but emphasizes that the cardiovascular benefit in high-risk populations (LDL persistently above 70 mg/dL on maximally tolerated statin, with established ASCVD) typically outweighs side-effect risk [6]
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Side effects tend to be most pronounced in the first few weeks of therapy and generally improve over time as your body gets used to the medication
An enlargement of the veins inside the scrotum that increases the temperature around the testes
It plays a role in cysteine storage
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