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These metabolic changes were supported by alterations in the gene expression of choline metabolism-related enzymes, such as choline dehydrogenase ( Chdh ), betaine-homocysteine methyltransferase ( Bhmt ), and DMG dehydrogenase ( Dmgdh ), and glycerophosphocholine phosphodiesterase 1 ( Gpcpd1 )
Statistical analyses The primary analysis estimand was the average treatment effect on the treated (ATT), estimated using a propensity score (PS) weighting approach in the on-treatment cohort
This mechanistically distinguishes GHK-Cus senolytic-adjacent (oxidative burden reduction) biology from Epitalons TERT-direct biology
By nature, an orally ingested health supplement is only efficacious if it can adequately cross the bloodgut barrier and enter into the circulatory system
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