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The changes in cardiac structure are paralleled by an age-related increase in myocardial fibrosis, predominantly by the increased deposition of collagen 1 and 3, that reduces tissue compliance to add to the progressive diminution in cardiac functional reserve [68,69]

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Headache during semaglutide treatment is primarily related to blood sugar fluctuations and dehydration rather than a direct effect of the medication on the central nervous system

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