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(7.2) Use In Specific Populations See 17 for PATIENT COUNSELING INFORMATION and Medication Guide

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This medicine is contraindicated in patients with known allergies to any of the active ingredients: Folic Acid, L-Carnitine / Levocarnitine, or Methylcobalamin

Helps with weight loss use over a 6-month period has been shown to cause a significant reduction in weight Neuroprotective beneficial effects on cognition, particularly in learning and memory Antidepressant effects increased availability of dopamine in the brain has been shown to increase BDNF levels Improved levels of insulin sensitivity a potential benefit for patients at risk from Type II diabetes Helps to increase energy expenditure by almost 6% Reduction in appetite with longer periods of satiety and reduced desire to eat Significant increase in fat oxidation and reduction in fat tissue What You Need To Know Combined with an effective diet, use of Tesofensine is comparable to gastric surgery and can result in similar weight reduction seen in such surgeries

BMJ Disease Reviews Finally, a systematic review and meta-analysis in JAMA Neurology (2025) pooling randomized cardiometabolic trials found no overall cognitive/dementia benefit across all cardioprotective diabetes drugs , but GLP-1 RAs stood out with a statistically significant reduction in incident dementia in subgroup analysesimportant but still Can GLP-1 Drugs Help Prevent Dementia