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Unlike caloric restriction alone, which often results in both fat and muscle loss, the peptides mechanism specifically targets adipose tissue without promoting protein catabolism

Higher doses do not necessarily produce better results and may increase the risk of side effects like headaches or gastrointestinal discomfort without improving fat loss outcomes

FDAs 2024 review summarized several early human studies and the later OPTIONS study

AOD9604 did not stimulate the production of IGF-1 in any of the systems studied, and elicits its fat-reducing effects without inducing insulin resistance a key pharmacological distinction from intact hGH that makes it a uniquely clean research tool for studying lipolytic mechanisms in isolation

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