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Agents in this group include peroxisome proliferator-activated receptor agonists (e.g., pioglitazone, elafibranor, saroglitazar), bile acid-farnesoid X receptor axis regulators (obeticholic acid), de novo lipogenesis inhibitors (aramchol, NDI-010976), and fibroblast growth factor 21/19 analogs
These will continue to roll out to members over the next several weeks
Both network meta-analyses favour retatrutide numerically and directionally, but the absence of direct RCT evidence means any comparative claim must carry a caveat
The FDA approved Wegovy in June of 2021, marking the first time since 2014 that federal health authorities had given the green light to a new weight loss drug
When someone loses weight quickly, whether from GLP-1s or another method, the liver releases extra cholesterol into the bile
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