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[Abstract] Pharmacol Res
Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)
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Amnesia was induced via intracerebroventricular (icv) administration of scopolamine at a dose of 70 nmol in 2 l artificial cerebrospinal fluid, with control animals receiving either aCSF or distilled water
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