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A multi-arm, phase 2, open-label study to assess the efficacy of RXC004 as monotherapy and in combination with nivolumab in patients with ring finger protein 43 (RNF43) or R-spondin (RSPO) aberrated, metastatic, microsatellite stable colorectal cancer following standard treatments

Malpartida AB, Williamson M, Narendra DP, Wade-Martins R, Ryan BJ (2021) Mitochondrial dysfunction and mitophagy in Parkinsons disease: from mechanism to therapy

In a proof-of-concept study, researchers from the University of Colorado Anschutz Medical Campus evaluated a subset of participants enrolled in the ongoing RESTORE clinical trial

3 This precipitated a series of events culminating in the Food and Drug administration (FDA) requirement for cardiovascular safety studies for all new hypoglycemic agents

A common oversimplification is to label all MAPKs as uniformly pro-inflammatory or pro-apoptotic (68). In reality, their effects are highly context-dependent, varying with cell type, stimulus intensity, duration, and cross-talk with other pathways