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This review examines dysregulation of the KP in MDD, emphasizing KP metabolites particularly quinolinic acid and kynurenic acid as biomarkers and mediators of excitotoxicity, neuroinflammation, and oxidative stress, and discusses the therapeutic efficacy of antidepressants that modulate this pathway
It is necessary for the healthy functioning of mitochondria at the cellular level
Approach Standard research cycle Duration 1224 weeks Off Period 48 weeks Best For Most planning windows
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