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12,13 Multiple clinical trials have been launched to therapeutically target key oncogenic signaling pathways in drug-resistant cancers, underscoring the translational relevance of this axis (Table 2)
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The tissue-specific activities are regulated by the interaction of many signalling pathways, notably the cAMP/PKA and PI3K/Akt pathways, which together mediate GLP-1's metabolic and protective effects
A 25-year prospective study of plasma adiponectin and leptin concentrations and prostate cancer risk and survival
Bikman emphasized that eating patterns, like frequent snacking , can reduce insulin sensitivity, contributing to age-related metabolic decline
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