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Based on these data, we propose the cyclization mechanism represented in Figure 3A , in which the formation of DKP would be dependent on the presence of the amino group in the lateral chain of AX
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137 Butyric acid can also activate GPR109a on macrophages, reduce the amount of pro-inflammatory mediators: cytokines IL-6 and Th17 cells, increase the levels of anti-inflammatory mediators: Treg cells and cytokines IL-10, and reduce vascular inflammation
Evaluation of primary study overlap To assess the potential risk of bias due to overlapping primary studies across the included meta-analyses, outcome indicators were first categorized by clinical system, and each outcome was assigned to a single system category
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