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A role in tumor development in patients with T2DM is also being investigated but further studies are required to fully understand the functions of GLP-1R and its agonists

Because it hits three receptors, slow dose escalation is essential due to increased GI sideeffect potential

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While GLP-1 RAs have demonstrated efficacy in reducing cardiovascular events and improving metabolic parameters, the magnitude of benefit appears greater with surgical intervention, particularly over the long term. The authors did emphasize that both treatment options are associated with substantial benefits, and they are not pointing to GLP-1 RA therapy as something that is ineffective or unsafe