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Established CMD is estimated to be present in 75% of HFpEF patients

Int J Mol Sci 22(14):7520

1 mol/L) and strychnine (1 mol/L) was added to the Ames medium to block voltage-gated Na + channels and glycine receptors, respectively

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Taken together, the above findings suggest that purine catabolism strongly associates with the TRP pathways leading to serotonin (5-hydroxytryptamine, 5-HT) and kynurenine metabolites