Conversely, the body's adjustment to improved glucose regulation after periods of hyperglycaemia may temporarily affect energy levels
Groups 4 and 5 (semaglutide 1.0 mg and 2.4 mg, respectively) discontinued placebo infusions
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HFD increases circulating levels of leptin and insulin, triggering local inflammatory responses, upregulation of pro-inflammatory cytokines such as TNF- and IL-6, and activation of the NF-B signaling pathway (Di Berardino et al., 2024