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We still dont know why people with diabetes (and obesity) dont lose as much weight compared with obesity without diabetes (as Drucker and I discussed in the companion podcast)

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In model experiments in pigs, they demonstrated that it was possible to completely protect infused GLP-1 against DPP-4 mediated degradation, and that this protection resulted in marked increase in the insulin response to glucose and GLP-1 (102)

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But prescription drugs often dont work as well in the real world outside of clinical trials

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Compounded semaglutide through platforms like TrimRx at $199 per month is often more affordable than brand-name options even with insurance coverage

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Accessed 4 Jun 2022 American Diabetes Association Professional Practice Committee

tirzepatide pens Switch to in T2D More Effective Than Upping Dulaglutide Dose Buy Tirzepatide 30mg Pen UK
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