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By combining these mechanisms, researchers can evaluate how coordinated receptor signaling influences metabolic function compared with single- or dual-receptor agonists [4]
Limitations of both the analysis reported here and previous meta-analyses are that the trials they include were not specifically designed to address these research questions, and that the trials included subjects at high risk of a CV event and, as such, may not be representative of the broader type 2 diabetes population
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Another trial investigating 15 weeks of LED and ET supplemented with weekly 30- to 60-minute multidisciplinary sessions (exercise, nutrition, and behavioural counselling) and wrist-worn activity monitoring reported significant improvements in the 6MWD and reductions in MLHF scores, with moderate correlations with weight loss [89]
Ask the prescriber before restarting after several missed doses
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