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As it finds peptides that are more likely to produce the desired effect, TD3B uses those examples to guide the next round of generation, making each step more productive. Testing TD3B In addition to evaluating the Direction Oracle, which achieved 93% accuracy in distinguishing agonist- and antagonist-like interactions, the researchers compared TD3B-generated candidates with known interaction patterns for GLP-1 drugs, a process similar to comparing a newly made key to one known to open a particular door