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SGLT2 inhibitors (sodium-glucose cotransporter-2 inhibitors) such as empagliflozin, dapagliflozin, and canagliflozin represent excellent alternatives, providing cardiovascular and renal protection alongside modest weight loss (typically 2-4 kg)

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Its FDA approval came after regulatory delays related to these cardiovascular concerns, and it is used selectively in patients in whom the benefits of rapid bone density improvement outweigh the cardiovascular risks

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