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It is important to note that metformin can significantly affect the levels of various metabolites, including those involved in the glucose metabolism, lipid metabolism, tricarboxylic acid cycle (TCA), and urea cycle (t Hart et al., 2018a)

This finding aligns with leptin resistance reported in other BBS models (24, 26) and suggests impaired leptin signaling within the hypothalamus of Bbs5 / mice

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